

Omega-3 Fatty Acids and Brain Function and Health
From last month's article, we know that omega-3's consist of two primary components, docosahexanoic acid (DHA) and eicosapentanoic acid (EPA). Recent studies suggest that these two fatty acids serve an integral role in brain development and function, especially (DHA). 1-4 Docosahexanoic acid (DHA) is the most abundant fatty acid found in the mammalian brain, and its levels in brain membrane lipids are altered by the type and amount of fatty acids in the diet, by both, increasing with development and decreasing with age.2-4 That means that DHA directly affects brain function and it plays an vital role, in regards to brain maturation. 3
DHA has also been shown to be involved with the growth and production of nervous tissue, as well as, aiding in neurogenesis, neurotransmission, and protection against oxidative stress.1 As you can see, the concentrations of DHA are the most abundant when the brain is still young and maturing. This conclusion is also indicative of why omega-3's function in children has become a popular area of interest. In a recent study, pregnant mothers that supplemented with omega-3's, had children that scored higher IQ's than the placebo group at 4 years of age. 5
An interesting link between omega-3 intake and depression has also been well documented. A study performed at the Department of Social and Preventative Medicine in Greece has shown that mildly depressed subjects have lower adipose tissue concentrations of DHA, when compared to non-depressed subjects. 6 Recent studies suggest that omega-3 supplementation may increase levels of serotonin and dopamine production in the brain, which are potent neurotransmitters that greatly affect mood. 7
Omega-3 Fatty Acids and Children
Omega-3's have already been shown to be directly involved with the development and overall function of the brain. Since the link between omega-3 fatty acids and brain development are so apparent, studies have been conducted to connect possible issues that could occur when omega-3 concentrations are insufficient. There has been evidence to suggest that deficiencies or metabolic imbalances between these fatty acids, might be associated with childhood development and psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD).8
An article published in 2005, involving omega-3 and omega-6 supplementation in schoolchildren with developmental coordination disorder (many with ADHD symptoms), showed improved scores in short-term memory tests and coordination. 9 Another study performed in 2003, documented an improvement in disruptive disorders with EPA supplementation and the link between DHA supplementation and neurodevelopment has already been well established. 9-10 All articles concluded that a known connection between low omega-3 concentrations in the brain and the occurrence of ADHD and other disruptive disorders are prevalent, but more studies are needed in the future.
A study performed at the Institute of Respiratory Medicine in Sydney, Australia, looked at the effects of omega-3 fatty acid supplementation in children with asthma. A questionnaire was sent to over 500 children that requested information about the frequency of asthma-like symptoms, such as, wheezing , airway hyper-responsiveness during exercise, and atopy (an allergy that predisposes individuals to allergic reactions). 11 Subjects were given oily fish once per week during the study and at the end, over 80% of the children displayed reductions in all three asthma-like symptoms. 11
Omega-3 Fatty Acids and Diabetes
Unfortunately, the prevalence of type 2 diabetes have been increasing exponentially over the past years. According to a survey conducted in 2007, over 18.2 million Americans have type 2 diabetes, with nearly 210,000 of that statistic being adolescences. 14 The blame can be placed on American’s consumption of processed foods that are loaded with high fructose corn-syrup, the carbohydrate equivalent to trans-fatty acids, and other "quick and convenient" foods that are practically devoid of any nutritional value. The result of years of consuming these types of foods are soaring insulin levels, along with the improper utilization of insulin in the body. Many studies have found that omega-3's can help alleviate many of these problems, as a preventative measure, as well as, a method of treatment. 12-13
A double-blind, placebo controlled study involving 50 patients with type-2 diabetes, were randomized to take either 2 grams of fish oil per day or a placebo, for a period of 10 weeks. At the end of the study, patients that took the fish oil showed significant improvements in controlling hyperlipidemia and glycemic control, while the placebo group showed no improvement. 12 Another study looked at the long-term effects of fish supplementation on insulin resistance and plasma lipoproteins in patients with hypercholesterolemia. At the end of the study, the patients displayed a reduction in plasma triglycerides, VLDL triglycerides, a significant enrichment in the erythrocyte phospholipid content of long-chain omega-3 fatty acids, without deteriorating blood glucose control. 13 This means that the patients showed substantial improvements by lowering elevated cholesterol levels, as well as, improving insulin control.
Works Cited
1 Dietary (n-3) Fatty Acids and Brain Development. By: Innis, Sheila M. Journal of Nutrition, Apr 2007, Vol. 137 Issue 4, p855-859, 5p; (AN 24570952).
2 Innis SM. Essential fatty acid metabolism during early development. In:
Biology of Metabolism in Growing Animals. Burrin DG ed. Pub.
Elsevier Science, B.V. Amsterdam, 2005. Part III, pp. 235–74
3 Guisto NM, Salvador GA, Castagnet PI. PAsquare SJ, Ilincheta de
Bschero MG. Age-associated changes in central nervous system glycerophospholipids composition and metabolism. Neurochem Res. 2002;
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4 Uauy R, Dangour AD. Nutrition in brain development and aging: role
of essential fatty acids. Nutr Rev. 2006;64:S24–33.
5 Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003 Jan;111(1):e39-44
6 Mamalakis G, Tornaritis M, Kafatos A. Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002 Nov;67(5):311-8.
7 Li H, Liu D, Zhang E. [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats] Wei Sheng Yan Jiu. 2000 Jan 30;29(1):47-9.
8 Plasma, red blood cells, phospholipids and clinical evaluation after long chain omega-3 supplementation in children with attention deficit/hyperactivity disorder (ADHD). By: Germano, Michele; Meleleo, Domenico; Montorfano, Gigliola; Adorni, Laura; Negroni, Manuela; Berra, Bruno; Rizzo, Angela M.. Nutritional Neuroscience, Feb2007, Vol. 10 Issue 1, p1-9, 9p, 6 charts, 5 graphs; DOI: 10.1080/10284150601153801; (AN 24827446)
9 Matsudiara T. Attention deficit disorders--drugs or nutrition?
Nutr Health. 2007;19(1-2):57-60. Review. P MID: 18309764
10 Colter AL, Cutler C, Meckling KA. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study.
Nutr J. 2008 Feb 14;7:8. PMID: 18275609
11 Hodge L, Solome CM, Peat JK, Haby MM, Xuan W, Woolcock AJ. Consumption of oily fish and childhood asthma. Med J Aust. 1996 Feb 5;164(3):137-40.
PMID: 8628130
12 Shidfar F, Keshavarz A, Hosseyni S, Ameri A, Yarahmadi S. Effects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes patients. East Mediterr Health J. 2008 Mar-Apr;14(2):305-13.
PMID: 18561722
13 Rivellese AA, Maffettone A, Iovine C, Di Marino L, Annuzzi G, Mancini M, Riccardi G. Long-term effects of fish oil on insulin resistance and plasma lipoproteins in NIDDM patients with hypertriglyceridemia. Diabetes Care. 1996 Nov;19(11):1207-13.
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http://www.bio-medicine.org/medicine-news/Survey-Reveals-Alarming- Prevalence-Rates-of-Diabetes-among-US-Adolescents-9866-1/Copyright © 2008 Planet Nutrition ™ . All rights reserved